Ophthalmic Drug R&D Platform

Ophthalmic diseases are niche drug discovery areas. A more knowledgeable and experienced R&D team in the relevant domains is needed for ophthalmic medication development because it is based on an understanding of ocular illnesses and changes in target tissue-specific expression.

Our company has developed a one-stop drug design and synthesis, pharmacodynamic, pharmacokinetic, toxicology, drug trial, and preclinical ophthalmic research platform for our customers, with a focus on the pharmacodynamic, pharmacokinetic, and safety evaluation of drugs for ophthalmic diseases.

For customers with needs related to the development of ophthalmic drugs, our research platform offers high-quality and effective experimental research services, expert registration application support, and project management services. It also incorporates cutting-edge drug delivery technologies and analytical methods.

Our Ophthalmic Drug R&D Platform

Our company's integrated ophthalmic research platform has built an extensive range of ophthalmic disease pharmacodynamic models and is led by medical experts with years of clinical ophthalmology experience to perform high-quality drug delivery and analytical evaluation studies in a variety of ophthalmic specialties, providing customers with a stable and high-quality non-clinical ophthalmic one-stop service.

Advanced Ophthalmic Drug Delivery Technology

Our platform is equipped with advanced ophthalmic surgical microscopes. In addition to conventional ophthalmic ointment dosing, we can achieve uniqueness for animal species such as rabbits, dogs, minipigs, and non-human primates. Available routes of drug delivery include:

• Microscopic subretinal injection.
• Suprachoroidal choroidal injection.
• Intravitreal injection.

Complete Ophthalmic Examination and Diagnostic Capabilities

The key to the preclinical evaluation of ophthalmic drugs lies in the fine manipulation and testing of the eyes of experimental animals with appropriate instruments. Our company has many years of practical experience and advanced equipment to solve various complex problems in ophthalmic research and provide stable, high-quality research services to our customers.

We have the Spectralis HRA + OCT ophthalmic imaging platform with the latest scalable modular design. We can use this system to help our clients complete fundus fluorescein angiography and optical coherence tomography. Specific tests that can be completed are as follows:

• Infrared for general fundus imaging.
• Radiofrequency for general fundus imaging.
• Fluorescein angiography (FA).
• Optical coherence tomography (OCT).

In addition, AlphaChem's comprehensive ophthalmic testing systems include slit lamps with digital camera systems, ophthalmometers, fundus lasers, indirect fundoscopic, and ophthalmic surgical microscopes.

Fig.1 Principles for animal dry eye modeling. (Zhu J, et al. 2022)

Extensive Animal Models for Ophthalmic Diseases

Our company has the ability to assist customers in establishing animal models for a wide range of ophthalmic diseases, including:

• Conjunctival tissue proliferation.
• Diabetic retinopathy (DR).
• Retinal neovascularization.
• Anophthalmia.
• Corneal neovascularization.
• Acute ocular inflammation model.
• Choroidal neovascularization (CNV) and subretinal fibrosis.

For more information, please feel free to contact us.

Reference

1. Zhu J, et al. (2022). "Application of Animal Models in Interpreting Dry Eye Disease." Sec. Ophthalmology. 9: 830592.

It should be noted that our service is only used for research, not for clinical use.