For many years, pharmacodynamic (PD) studies have been part of the non-clinical evaluation of drugs used by humans worldwide. Our company is committed to providing professional PD solutions for human drug use by conducting systematic and rigorous PD evaluations that will provide an adequate experimental basis for the efficacy and safety of drugs in clinical trials.
Fig.1 Factors affecting the pharmacokinetics and pharmacodynamics of a drug. (Lange E, et al. 2013)
Our solutions combine new theories and technologies to systematically construct various pharmacodynamic evaluation models and evaluation criteria for the preclinical PD evaluation of various new drugs in cellular, tissue, and whole animal models for different mechanisms of action around innovative drugs for oncology, neuropsychiatric, cardiovascular, immunology, and diabetes, among other important diseases.
In Vitro PD Research
The specialist in vitro PD team at Our company has a wealth of research expertise in a wide range of disease areas, target types, and assays and equipment. We may offer comprehensive biochemical, biophysical, and cytological studies in the drug development and IND process.
| Biophysical Detection | Surface plasmon resonance, thermodynamic stability assay, isothermal titration calorimetry, biofilm interference, temperature-dependent fluorescence intensity change, etc. |
| Biochemical Detection | Light absorption, chemiluminescence, fluorescence, fluorescence polarization, time-resolved fluorescence resonance energy transfer, enzyme-linked immunoassay, enhanced chemiluminescence homogeneous affinity assay, etc. |
| Cytology Assays | - Cell viability, apoptosis, proliferation, death and cell cycle assays.
- Cell migration assays.
- Cell infiltration assays.
- Cellular uptake assays.
- Signaling pathway assays.
- siRNA gene knockdown.
- CRISPR/Cas9 gene modification.
- Stable expression cell line construction.
- HTRF protein expression level detection: immunoblotting, immunostaining, time-resolved fluorescence resonance energy transfer.
- Flow cytometry technology
- Cell co-culture technology.
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In Vivo PD Research
Our company's in vivo PD research team focuses on oncology and cardiovascular diseases, and has accumulated extensive experience in disease modeling, PD evaluation, and screening.
Oncology
Our company has successfully constructed many human and murine cell line transplantation mouse models, including lung, colon, pancreatic, kidney, prostate, glioma, lymphoma, gastric, ovarian, and leukemia.
Cardiovascular Diseases
- Cardiovascular system (myocardial ischemia, hyperlipidemia and atherosclerosis, heart failure, heart rate disorders, hypertension, etc.)
Neurodegenerative Diseases
- Central/peripheral nervous system (cerebral ischemia, Alzheimer's disease, depression/anxiety, drug dependence, etc.)
Other Diseases
If you are looking for the best solution in the field of PD studies of drugs for human use, please feel free to contact us.
Reference
- Lange E, et al. (2013). "The Mastermind Approach to CNS Drug Therapy: Translational Prediction of Human Brain Distribution, Target Site Kinetics, and Therapeutic Effects."; Fluids and Barriers of the CNS. 10(1): 12.
Related Services
It should be noted that our service is only used for research, not for clinical use.
